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SUMMARY:The Lysine acetyl transferase PCAF/Kat2b in the control of glucose
  metabolism and insulin secretion
DTSTART:20140506T110000
DTEND:20140506T120000
DTSTAMP:20260928T200351Z
UID:594c15c9918307a69d12f5ebf14175dd78bb7f5f842a4ecb004a9141
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Jean-Sébastien Annicotte\, CNRS\, Lille (F)\nSEMINAR of t
 he LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANCE (LIMNA)Abstract:
 \nPancreatic β-cells control insulin secretion through a fine-tuned proce
 ss. Dysfunctions of this particular cell type are at the origin of patholo
 gical conditions\, such as Diabetes Mellitus. A common component of the tw
 o type of diabetes\, i.e. immune type 1 and non-immune type 2 (T2D)\, is a
  decrease of β-cell function and/or mass\, finally resulting in hyperglyc
 emia and its subsequent deleterious consequences. Therefore\, a complete u
 nderstanding of the factors and mechanisms responsible for β-cell mainten
 ance and function could be of interest for the treatment of diabetes.\nThe
  P300-CBP Associated Factor (PCAF/Kat2b) is a lysine acetyl transferase cl
 osely related to P300\, CBP and GCN5. By using in vitro β-cell lines\, Pc
 af -/- global KO mice and human T2D islets\, I will present data showing t
 hat PCAF is a key factor involved in the control of glucose metabolism thr
 ough its direct role on insulin secretion. Global gene expression and ChIP
 -seq experiments reveal that PCAF controls a subset of target genes involv
 ed in the unfolded protein response/ER stress pathway. Our findings identi
 fy PCAF as a new player in type 2 diabetes physiopathology\, and modulatin
 g its activity by pharmacological compound could represent an interesting 
 therapeutic avenue for the treatment of T2D.Bio:\nPhD thesis at IGBMC\, St
 rasbourg (F)\nPostdoc at University of Montpellier and INSERM\, Montpellie
 r (F)\nCurrent: Group Leader\, Molecular Basis and Modelization of Diabete
 s and Obesity Laboratory\, European Genomic Institute for Diabetes\, CNRS 
 UMR 8199\, Lille (F)
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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