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SUMMARY:Transcriptional regulatory network controlling hepatic fatty acid 
 metabolism
DTSTART:20140513T100000
DTEND:20140513T110000
DTSTAMP:20260609T201338Z
UID:a2fa04495379965a3740bd5c4f491d27b2e4bc77eeb1595ab885101f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Celia Martinez\, PhD\, Health Research Institute Hospital La F
 e\, Valencia (E)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRI
 TION ALLIANCE (LIMNA)Abstract:\nHepatic fatty acid metabolism is a tightly
  controlled process that involves regulation at the levels of uptake\, oxi
 dation\, de novo synthesis and export to the circulation. Regulation is ac
 hieved by the action of hormones\, like insulin\, or intracellular metabol
 ites\, notably fatty acids and sterols\, that can activate transcription f
 actors\, including nuclear hormone receptors (PPARa\, PPARg\, LXR)\, the c
 arbohydrate response element binding protein ChREBP and the sterol regulat
 ed factor SREBP1c. Control of the metabolic transcription factors should b
 e a coordinated process\, since in most cases multiple factors are involve
 d in the regulation of different sets of genes under specific metabolic st
 ates. In this case\, HNF4a is of particular interest given its crucial fun
 ction in a regulatory network required for maintenance of the hepatic phen
 otype\, as well as its role in the regulation of several metabolic metabol
 ic genes involved in gluconeogenesis\, bile acid synthesis\, conjugation a
 nd transport.  
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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