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SUMMARY:Making sense of muscle stem cell heterogeneities
DTSTART:20140502T110000
DTEND:20140502T120000
DTSTAMP:20260428T073721Z
UID:eb07aade292a9dca1f8c12b1757b6ba66ed70c75cca078047fa0cfc4
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Shahragim Tajbakhsh\nThe regulatory cell state of muscle s
 tem cells fluctuates during perinatal growth\, after entering quiescence\,
  and following muscle injury when amplification of the stem cell pool resu
 lts in the production of myoblasts and future self-renewing cells. We have
  noted a heterogeneity in the muscle stem cell pool during quiescence and 
 proliferation. A major regulator of cellular quiescence in this tissue is 
 Notch signaling\, which is lost rapidly following cell cycle reentry\, the
 n restored during self-renewal. We and others have reported that Notch sig
 naling could mediate the stability of the niche by regulating extracellula
 r matrix molecules. These observations will be discussed in the context of
  regulation and maintenance of the stem cell state
LOCATION:SV 1717a http://plan.epfl.ch/?room=SV%201717A
STATUS:CONFIRMED
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