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SUMMARY:The Randle cycle revisited: direct regulation of anabolic and cata
 bolic pathways  in skeletal muscle by PGC-1alpha      
DTSTART:20101214T110000
DTSTAMP:20260916T212924Z
UID:416725fe165d4f5a0534388a09fda9bf94e71538edb5d5d1269933ab
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Christoph HANDSCHIN - University of Basel\, Switzerland\nT
 he peroxisome proliferator-activated receptor gamma coactivator 1alpha (PG
 C-1alpha) is a central regulator of fiber plasticity in endurance-trained 
 skeletal muscle. Upon activation by physical activity\, PGC-1alpha control
 s the metabolic and myofibrillar programs that are prototypical of oxidati
 ve\, high-endurance muscle fibers. We now provide evidence that in additio
 n to boosting lipid oxidation\, PGC-1alpha also directly regulates anaboli
 c pathways in muscle\, in particular de novo lipogenesis. Thereby\, storag
 e of lipids is promoted\; these triglycerides are the substrates for ATP g
 eneration during endurance exercise bouts in trained athletes. Our finding
 s have important cautionary implications for the development and applicati
 on of "exercise mimetics"\, drugs that are designed to elicit an endurance
 -trained phenotype even in sedentary individuals.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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