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SUMMARY:Acute Hypoglycemia Induces Retinal Cell Death in Mouse 
DTSTART:20101209T093000
DTSTAMP:20260406T064252Z
UID:21fe047fba4b3f67815c443175651b78285e1f3af88561f4e254d3c9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Raphael RODUIT\, IROVISION\, Sion\, Switzerland\nGlucose i
 s the most important metabolic substrate of the retina and maintenance of 
 normoglycemia is an essential challenge for diabetic patients. Glycemic ex
 cursions could lead to cardiovascular disease\, nephropathy\, neuropathy a
 nd retinopathy. A vast body of literature exists on hyperglycemia namely i
 n the field of diabetic retinopathy\, but very little is known about the d
 eleterious effect of hypoglycemia. Therefore\, we decided to study the rol
 e of acute hypoglycemia in mouse retina. \n\nWe showed that a 5-hour hyper
 insulinemic/hypoglycemic clamp induces retinal cell death via caspase 3 ac
 tivation and decrease of GSh content. In vitro experiments confirmed the l
 ow-glucose induction of 661W cell death via superoxide production and acti
 vation of caspase 3\, which was also concomitant with a decrease of GSH co
 ntent. Moreover\, complementation with extracellular glutathione ethyl est
 er (GSHee) at low glucose restored GSH level and reduced apoptosis.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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