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SUMMARY:Differentiation and functions of monocyte/macrophages
DTSTART:20101118T121500
DTSTAMP:20260506T044831Z
UID:6eab0f391f0ef4596ca779cc1ec95ec138d6d22c496f0ba4d579c1b3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Frederic Geissman\, INSERM\, Necker-Enfants Malades research I
 nstitute\nMonocytes and macrophages are critical effectors and regulators 
 of inflammation and the innate immune response\, whereas dendritic cells i
 nitiate and regulate adaptive immune responses\, and are central to the de
 velopment of immunologic memory and tolerance. Recent in vivo experimental
  approaches in the mouse have unveiled new aspects of the developmental an
 d lineage relationships among these cell populations. Monocytes\, macropha
 ges and dendritic cells subsets share a common bone marrow progenitor\, th
 e MDP (Macrophage and DC progenitor)\, which express receptors for SCF\, M
 -CSF and FLT3-L\, and the chemokine receptor CX3CR1. However\, distinct su
 bsets of dendritic cells and macrophages are generated via separate differ
 entiation pathways\, which are beginning to be elucidated. Blood monocytes
  themselves consist in several functional subsets. A classical Gr1+ popula
 tion of 'inflammatory' monocytes give rise to 'inflammatory' DCs while a s
 econd subset (Gr1-) have been shown to patrol blood vessels in the steady 
 state\, extravasate during infection or tissue damage\, and give rise to '
 M2'-type macrophages that may be involved in tissue repair. Despite this\,
  the origin\, differentiation cues\, and precise functions for many tissue
  macrophages\, monocytes\, and dendritic cell subsets in mice remain to be
  elucidated. Another challenge that will be discussed is to identify corre
 sponding cell populations in humans.
LOCATION:SV 1717A
STATUS:CONFIRMED
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