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SUMMARY:Benefits of an erratic boss : Gene expression noise facilitates th
 e evolution of gene regulatory interactions
DTSTART:20140430T110000
DTEND:20140430T120000
DTSTAMP:20260427T233055Z
UID:ddb40eda4cbd40378ee35e50278f652ca8ab5a8b4d6354721bfa95f9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Erik van Nimwegen\nIn studies of gene regulation\, it is o
 ften tacitly assumed that the interactions between transcriptional regulat
 ors and their target promoters are finely tuned to ensure condition-approp
 riate gene expression levels of the targets. However\, how natural selecti
 on might evolve such finely tuned regulation from an initial state without
  regulation\, is rarely discussed. Similarly\, whereas many recent studies
  have shown that gene expression is noisy and that some genes exhibit much
  higher expression noise than others\, it is poorly understood how natural
  selection has acted on expression noise. I will present a combination of 
 experimental evidence (based on comparison of native and synthetically evo
 lved E. coli promoters) and theoretical modeling\, arguing that the evolut
 ion of gene expression noise is intimately coupled to the evolution of gen
 e regulatory interactions.
LOCATION:SG 0211 https://plan.epfl.ch/?room==SG%0200211
STATUS:CONFIRMED
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