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SUMMARY:Functional Interrogation of the Cancer Genome
DTSTART:20140501T150000
DTEND:20140501T160000
DTSTAMP:20260506T084451Z
UID:a7bab243c17b3f1255d15c02114f00952d885cd2c577631459ae64e8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Kartiki Desai\nAbstract: Extracellular receptors and/or 
 secreted growth factors that drive cancer metastasis make provocative targ
 ets as they are easily accessible on the cell surface and usually show hig
 h response rates at lower drug doses\, resulting in negligible side effect
 s. To discover novel candidate receptor/secreted oncogenes\, we used a who
 le-genome data-mining approach that takes advantage of large microarray st
 udies of breast tumors annotated for clinical outcomes. Based on analysis 
 of 14 independent breast cancer cohorts (2027 patients)\, we identified mo
 re than 30 cell surface/secreted proteins that when expressed highly\, wer
 e associated with poor patient survival across multiple cohorts. This enri
 ched gene set offered unexplored opportunities for immunotherapy and ?drug
 ? development. We established a cell-based screening platform to prioritiz
 e the most clinically relevant genes\, and explored pathways downstream to
  each candidate in order to develop assay read-outs. One candidate molecul
 e\, JMJD6\, a bifunctional histone arginine demethylase and hydroxylase em
 erged as a marker of tumor aggressiveness\, therapy resistance and affecte
 d both cell growth and motility. We will discuss molecular details involve
 d and our efforts to understand its complete function in oncogenesis.
LOCATION:AI 1.153 http://plan.epfl.ch/?lang=fr&zoom=20&recenter_y=5864127.
 68295&recenter_x=730529.34707&layerNodes=fonds\,batiments\,labels\,informa
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 3
STATUS:CONFIRMED
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