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SUMMARY:Biophysical Viewpoint on Designing a Diagnostic Test
DTSTART:20140501T160000
DTSTAMP:20260414T071552Z
UID:edc68e3c84f14157c2ba7b1f87d5f34ea13851d3c18b93edb46b035b
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Sergey Y. Tetin\nDiagnostics Research\, Abbott Diagnostics 
 Division\, Abbott Park\, IL 60064\nApplication of biophysical tools facili
 tates the design of robust diagnostic immunoassays. We implemented several
  biophysical methods including X-ray and NMR analysis\, fluorescence fluct
 uation spectroscopy and fluorescence microscopy\, to perform structure-fun
 ction and binding characterizations of the assay components. Measuring per
 tinent equilibrium and kinetic coefficients of antibodies and related targ
 et molecules reveals the inherent limits in using specific reagent combina
 tions imposed by the detection concentration range and chosen incubation t
 imes. The apparent kinetic rates at each assay step were used to compute t
 he assay calibration plot. The experimental assay results were found to be
  in good agreement with the computed data confirming that applying biophys
 ical tools provides a solid foundation for immunoassay design and optimiza
 tion.\nHost :\nProf. Martin Gijs - EPFL / STI / IMT\nBio: Dr. Tetin\, M.D.
 \, Ph.D.\, earned his degrees in Ukraine. He came to the University of Ill
 inois at Urbana Champaign in 1991 as a postdoctoral fellow and then held a
 n academic position at Texas A&M University.  In 1996 he joined Abbott. C
 urrently\, he is the Head of the Molecular Binding Characterization group 
 in the Diagnostics Division. His group pioneers in the development of new 
 ultra-sensitive techniques for detection of molecular interactions and pro
 vides scientific guidance in reagent selection for diagnostic immunoassays
 . Dr. Tetin is a Research Fellow in the Volwiler Society\, which recognize
 s outstanding research achievements at Abbott. He is also a member of the 
 Advisory Board for NIH Resource Center\, Laboratory for Fluorescence Dynam
 ics\, at UC Irvine.
LOCATION:BM1 130 http://plan.epfl.ch/?lang=en&room=bm1130
STATUS:CONFIRMED
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