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SUMMARY:Exploring the Interactions of Ions\, Peptides\, and Proteins with 
 Lipid Membranes
DTSTART:20140505T121500
DTSTAMP:20260930T202132Z
UID:b889a55f74c84bc2a76878895b0b3bade775f721d834332e684bf0ab
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Paul S. Cremer\, Penn State University\, University Park
 \, PA (USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERINGAbstract:\nBio
 logical membranes often contain negatively charged lipids such as phosphat
 idylserine\, phosphatidylglycerol\, phosphatidic acid\, and gangliosides. 
 The head groups of these lipids can strongly interact with positively char
 ged amino acids from peptides and proteins (i.e. Arg and Lys residues)\, m
 etal cation from the extracellular solution\, as well as positively charge
 d drug molecules. These negatively charged lipids are highly regulated wit
 hin cells and are highly abundant in certain organelles while almost compl
 etely absent in others. Moreover\, their concentration within a particular
  leaflet of a given membrane is often tightly regulated. Despite the high 
 degree of control of lipid composition within cells\, little is often know
 n about the reason for it or even the specific nature of ligand-receptor b
 inding interaction with such moieties. To remedy this\, we have employed a
  combination of spectroscopic techniques (Figure 1)\, microfluidic platfor
 ms\, monolayer and planar supported bilayer architectures to explore the s
 pecific biophysical chemistries of these interactions. This includes the d
 evelopment of a novel analytical tool that employs a pH sensitive fluoroph
 ore to probe subtle changes in the surface potential of lipid bilayers upo
 n ligand or ion binding. Both thermodynamic and molecular level details of
  these systems have been obtained. The results reveal that binding can be 
 highly dependent on the concentration of specific lipids within the membra
 ne. Moreover\, the presence or absence of various uncharged lipids can als
 o greatly influence the binding properties. Interestingly\, specific inter
 actions involving hydrogen bonding\, charge transfer\, and hydrophobic int
 eractions often dominate over simple electrostatic effects.Bio:\nEducation
 :\nPh.D. in Chemistry\, University of California\, Berkeley\, 1996\nB.A.\,
  University of Wisconsin-Madison\, 1990\nPositions held:\nProfessor of Che
 mistry (major appointment)\, Penn State University\, State College\, PA\nP
 rofessor of Biochemistry and Molecular Biology (minor appointment)\, Penn 
 State University\, State College\, PA\nDistinguished Professor of Chemistr
 y\, Texas A&M University\, College Station\, TX (2012)\nProfessor of Chemi
 stry\, Texas A&M University\, College Station\, TX (2004-2012)\nAssociate 
 Professor of Chemistry\, Texas A&M University\, College Station\, TX (2002
 -2004)\nAssistant Professor of Chemistry\, Texas A&M University\, College 
 Station\, TX (1998-2002)
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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