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SUMMARY:Inflammasome Activated Caspase 7 Cleaves ARTD1 to Enhance the Expr
 ession of a Subset of NF-kappaB Target Genes in Macrophages
DTSTART:20120125T110000
DTSTAMP:20260502T004947Z
UID:c746d9e46ac363495465a5a77eaea712ab02740d71891da35428ce7a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Michael HOTTIGER University of Zurich-Irchel - Institute o
 f Veterinary Biochemistry & Molecular Biology -  Zürich\nCaspase 1 is par
 t of the inflammasome\, which is assembled upon pathogen recognition\, whi
 le caspases 3 and/or 7 are mediators of apoptotic and non-apoptotic functi
 ons. ADP-ribosyltransferase Diphtheria toxin-like 1(ARTD1\, formerly calle
 d poly-ADP-ribose polymerase 1 (PARP1)) cleavage is a hallmark of apoptosi
 s yet not essential\, suggesting it has another physiological role. Here w
 e show that after LPS stimulation\, caspase 7 is activated by caspase 1\, 
 tanslocates to the nucleus and cleaves ARTD1 at the promoters of a subset 
 of negatively regulated NF-kappaB target genes. Mutating the ARTD1 cleavag
 e site D214 renders ARTD1 uncleavable and inhibits ARTD1 release from chro
 matin and chromatin decondensation\, thereby restraining the expression of
  cleavage-dependent NF-kappaB target genes. These findings propose an apop
 tosis-independent regulatory role for caspase 7-mediated ARTD1 cleavage in
  pro-inflammatory gene expression and provide novel insight into inflammas
 ome signaling.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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