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SUMMARY:Label-free SPR and SPRi analysis with plasmonic microarrays and ca
 lcinated nanofilms
DTSTART:20140512T170000
DTEND:20140512T180000
DTSTAMP:20260921T202811Z
UID:bd52d865819fa6e32df375b01f01ae3d247e5ccd9e1fa5972f50a386
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Quan Jason Cheng\, University of California\, Department
  of Chemistry\, Riverside\, CA\, USAhttp://research.chem.ucr.edu/groups/ch
 eng/home_page_8.htm\nLabel-free detection of molecular interactions presen
 ts an attractive alternative to traditional label-based techniques such as
  fluorescence. As one of the most advanced label free techniques\, surface
  plasmon resonance (SPR) continues to be at the forefront of evolving sens
 ing technology. However\, there are still challenging issues for SPR and S
 PR imaging methods\, in particular acquisition of quality raw data for ima
 ging analysis and limited success towards orthogonal detection. This semin
 ar will discuss several new strategies in the design of high performing SP
 R biochips. Using spatial variation of the metal thickness and resonance c
 onfinement\, manipulation of the metal film leads to attenuation of the ev
 anescent field in the background area\, while enabling the excitation of S
 PPs inside the desired patterns. In addition\, micro-patterned glass subst
 rate is developed to de-couple resonance in the resonance angle between th
 e wells and the surrounding area\, resulting in the isolation of the array
  spot resonance with a significant reduction of the background signal. Fab
 rication of calcinated nanofilms for facilitating the establishment of bio
 mimetic interfaces will be presented. Nanoscale silicate layers are constr
 ucted with a layer-by-layer (LbL) deposition/calcination process\, where p
 hotolithographic techniques can be applied to generate various structures 
 including channels and microarrays for throughput study. Calcination of na
 noparticle-based monolayer plasmonic films has also been developed for imp
 roving sensitivity and enabling orthogonal detection including onchip mass
  spectrometry and SERS analysis. Applications of the calcinated nanofilms 
 in membrane stability assessment\, signal amplification towards ultrasensi
 tive detection\, and in situ construction of a polymer coating for investi
 gation of cell adhesion using host-guest reactions will be presented.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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