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SUMMARY:Learning on the fly:  Innate Immune Recognition and Signal Transdu
 ction in Drosophila  
DTSTART:20140520T140000
DTEND:20140520T150000
DTSTAMP:20260510T062909Z
UID:81114e0968a270efed31ef11c85d474cf52da99f8989c513efed0f8f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Neal Silverman\, PhD -  Division of Infectious Diseases and I
 mmunology - University of Massachusetts Medical School\nInsects\, like Dro
 sophila\, rely on innate immune responses to effectively combat a wide ran
 ge of infectious diseases.  In response to bacterial challenge\, Drosophi
 la trigger NF-kB signaling pathways which drive the robust production of a
  battery of antimicrobial peptides.  In particular\, peptidoglycans\, fro
 m the cell wall of most bacteria\, are potent activators of  the two Dros
 ophila NF-kB pathways\, the Toll and Imd pathways.  The amino acid consti
 tuents of the peptidoglycan\, which varies amongst different types of bact
 eria\, determines wether the Toll or Imd pathways is activated.  For exam
 ple\, the Imd pathways detects DAP-type peptidoglycan from Gram-negative b
 acteria and activates the NF-kB precursor Relish.  Similar to mammalian N
 F-kB signaling pathways\, the Imd pathway utilizes K63-polyubiquitination\
 , in a dynamic process\, involving caspase cleavage and Iap proteins\, to 
 drive NF-kB activation and potent immune responses.  More recent studies 
 have uncovered a novel feedback mechanism to regulate this inflammatory pa
 thway through modifying the ubiquitination processes. Dr. Silverman will p
 resent the most recent findings from his group on the molecular mechanisms
  underlying bacterial recognition and signal transduction in the Drosophil
 a Imd pathway.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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