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SUMMARY:High-resolution lensless microscopy and nonlinear imaging: new too
 ls for biomedical applications
DTSTART:20140522T163000
DTEND:20140522T173000
DTSTAMP:20260506T190054Z
UID:d28c06560764748800a6bfc795c3e651fbaf95b5fdecb1180cff0bb8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Stefan Witte Free\, University of Amsterdam\nThe ability to
  image biological objects at the sub-cellular level is of major importance
  for life science and clinical diagnostics. Especially in neuroscience\, l
 abel-free 3D microscopic imaging modalities are highly needed.\nIn this ta
 lk\, I will present our research efforts on third-harmonic generation (THG
 ) microscopy\, which we have shown to be a powerful technique for live bra
 in imaging with sub-cellular resolution [1]. THG microscopy allows high-re
 solution structural imaging of grey and white matter as well as red blood 
 cells with good contrast\, and even enables guided patch clamping deep ins
 ide brain tissue.\nIn the quest towards ever higher resolution\, we have r
 ecently started a research project on soft-X-ray imaging\, with the goal o
 f single-cell imaging at ultrahigh resolution\, using a compact table-top 
 setup based on high-harmonic generation. As this is a wavelength range whe
 re good-quality imaging optics are problematic\, we are working on the dev
 elopment of high-resolution lensless imaging techniques. I will discuss ou
 r results on lensless diffractive imaging with ultra-broadband sources [2]
 \, as well as our progress towards soft-X-ray imaging.\n[1]S. Witte\, A. N
 egrean\, J.C. Lodder\, C.P.J. de Kock\, G.T. Silva\, H.D. Mansvelder\, M.L
 . Groot\, Proc. Natl. Acad. Sci. USA 108\, 5970 (2011).\n[2] S. Witte\, V.
 T. Tenner\, D.W.E. Noom\, K.S.E. Eikema\, Light: Sci. Appl. 3\, e163 (2014
 ).
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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