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SUMMARY:Bone Marrow Adiposity and Myelopoiesis in PPARγ Null Mice
DTSTART:20140519T133000
DTSTAMP:20260427T200841Z
UID:950165b801811cef99487158b9cbd0e7993fe669dfb3f2eb72e486c0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Béatrice Desvergne\, Center for Integrative Genomics\, 
 University of Lausanne (CH)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERI
 NGAbstract:\nBone physiology and hematopoiesis are intimately linked. Adul
 t hematopoiesis takes place in the bone cavity\, where a variety of cells 
 and molecular contacts create a niche allowing hematopoietic stem cells (H
 SCs) to undergo cell division and differentiation in a highly regulated ma
 nner. Adipocytes are also present in the bone marrow and their contributio
 n to the stem cell niche has been proposed. The nuclear receptor Peroxisom
 e proliferator-activated receptor-γ (PPARγ) is critically required for a
 dipocyte differentiation. PPARγ activation also acts on bone physiology v
 ia inhibition of osteoblast formation and promotion of adipocyte different
 iation from common mesenchymal progenitors. To explore the systemic and lo
 cal importance of adipose tissue\, we generated a mouse model carrying a c
 onstitutive deletion of PPARγ\, which is totally deprived of any form of 
 adipose tissue. As a result\, deletion of PPARγ and/or lack of adiposity 
 in the bone marrow cavity activates long-term HSCs (LT-HSCs) and promotes 
 myelopoiesis from bone marrow progenitors. This is accompanied by severe e
 xtramedullary hematopoiesis (EMH). Data emphasizing  the role of bone mar
 row adiposity in setting the appropriate bone marrow microenvironment for 
 bone homeostasis and hematopoiesis will be presented.Bio:\nBéatrice Desve
 rgne was trained as a MD. In 1984\, she obtained both the MD degree and th
 e specialization in Anesthesiology and Resuscitation. After practicing med
 icine for a few years\, she decided to devote more time for fundamental re
 search. She thus carried out a post-doctoral stay from 1988 to 1992 at the
  National Institutes of Health in Bethesda\, first as visiting fellow and 
 then visiting associate in the National Institute of Diabetes and Digestiv
 e and Kidney Diseases\, in the field of Molecular Endocrinology. In 1992\,
  she was appointed as assistant professor at the University of Lausanne. S
 he was then recruited as associate professor at the same University\, join
 ed the Center for Integrative Genomics in 2003\, and was promoted as full 
 professor in 2008. In addition to her teaching and research activities\, s
 he was elected President of the Section of Fundamental Sciences from Janua
 ry 2009 to July 2012 and appointed as the Vice-Dean of the Faculty of Biol
 ogy and Medicine from August 2009 to July 2012. In August 2012\, she has b
 een elected as the new Dean of the Faculty of Biology and Medicine.\nHer r
 esearch interests focus on understanding nuclear receptors from their mole
 cular mechanism of action to their implication in development and homeosta
 sis processes. Accordingly\, the approaches that she uses gives a lot of i
 mportance to in vivo observations\, as the lead for exploring and understa
 nding their molecular explanations. She also has a broad interest in inter
 disciplinary sciences and holds a bachelor degree in Philosophy. With that
  respect\, she is an important actor in organizing teaching around science
 s\, techniques\, and society within the cursus of Biology students at the 
 University of Lausanne.
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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