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SUMMARY:DNA regulatory regions: the logic\, variability and rules of assoc
 iation
DTSTART:20140630T103000
DTEND:20140630T113000
DTSTAMP:20261001T173701Z
UID:0f006a402ef1e40dca5f993ff0732356a7451c88c9ccd8c3e2a3e2a6
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Mikhail Spivakov\nRegulatory Genomics Group\nBabraham Inst
 itute\, Cambridge UK\nBIOENGINEERING SEMINARAbstract:\nDNA regulatory regi
 ons\, such as promoters and enhancers\, are the key nodes of transcription
 al control in time and space. Previous work by ourselves and others on the
  organisation and variability of regulatory regions has suggested signific
 ant flexibility and robustness in their design. The fact that genes are of
 ten controlled by multiple regulatory regions adds another degree of freed
 om to gene regulation. We are currently investigating the "rules of associ
 ation" between DNA regulatory regions in the context of enhancer-promoter 
 interactions\, as well as during V(D)J recombination\, a process that also
  involves the formation of DNA looping contacts. Our work in progress on t
 hese topics\, along with previous research\, paints a picture of the gener
 ally probabilistic nature of cis-regulatory organisation\, with multiple s
 tochastic events combining into deterministic outcomes.Bio:\nMikhail Spiva
 kov graduated from Department of Biology at Moscow State University in 200
 2 and moved to London to do a PhD with Amanda Fisher and Matthias Merkensc
 hlager at MRC Clinical Sciences Centre (Imperial College). His PhD project
 s investigated chromatin events underlying cell differentiation\, and abou
 t half of his work was ‘wet-lab’ and half computational.\nMikhail then
  joined EMBL on an Interdisciplinary Fellowship to work with Ewan Birney (
 EMBL-EBI\, near Cambridge) and Eileen Furlong (EMBL Heidelberg) on the reg
 ulatory organization of cardiac enhancers. At EMBL\, he also contributed t
 o the ENCODE project\, studying the population genetics of transcription f
 actor binding sites. In addition\, Mikhail has been involved in the establ
 ishment of a population genomics resource in medaka fish that will become 
 available in 2014.\nIn November 2012\, Mikhail started a Regulatory Genomi
 cs group at the Babraham Institute as part of the Nuclear Dynamics Program
 me.
LOCATION:SV1717A http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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