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SUMMARY:Industrial Designs and Use of Microreactors.
DTSTART:20110520T101500
DTSTAMP:20260601T105136Z
UID:73a0d48ea1d432a83b7feef43321c600070d295b7992d36587ce28cc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. D. Roberge\, Department of Process Research\, LONZA Ltd.\,
  Visp\, Switzerland.\nMicroreactor Technology enables processes to be run 
 in a continuous manner using a minimal quantity of reagent. Thus\, it perm
 its the rapid and scalable development of continuous processes in the fine
  chemical and pharmaceutical industries. Under such circumstances\, advant
 ages are associated to the continuous way of operation and to the micro st
 ructure as well such as the good thermal control. It is important to diffe
 rentiate from where the advantage is coming from because it will significa
 ntly influence the scale up strategy for larger productions.\nIn the fine 
 chemical industry\, productions are made in multi-purpose plants of high f
 lexibility. The integration of a continuous system is such an environment 
 is feasible given appropriate modules are employed with (i) good chemical 
 resistance (i.e. glass\, Hastelloy\, Teflon)\, with (ii) excellent materia
 l stability over a large range of temperatures\, and with (iii) ease of co
 nnection avoiding dead volume. In addition the various modules need to tak
 e into account the physico-chemical properties of the reaction such as the
  reaction kinetics (==> residence time) and the reaction phases (solid –
  liquid – gas). This approach leads systematically to a toolbox concept.
 \nA detailed analysis at Lonza showed that ca. 50% of the reactions studie
 d could fit into a microreactor based on their kinetic. However\, by takin
 g into account the reaction phases\, this number shrinks to ca. 20% of pot
 ential candidates because a solid phase is present in more than 60% of the
  cases. In addition\, the reactions were classified into 3 classes namely 
 Type A (mixing controlled reactions)\, Type B (rapid but kinetically contr
 olled reactions)\, and Type C reactions (batch reactions with thermal haza
 rd).\nThe 3 types of reaction define of course 3 types of reactor modules 
 required to operate in a flexible manner various pharmaceutical reactions.
  This talk will present an analysis of the industrial designs of reactors\
 , review their use\, and address in details the scale-up concept. The Lonz
 a MicroReactors have already produced several tons of material. Thus\, man
 ufacturing examples will be presented based on Lonza experience showing th
 e applicability of continuous processes and microreactors in an industrial
  environment.
LOCATION:ME C2405
STATUS:CONFIRMED
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