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PRODID:-//Memento EPFL//
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SUMMARY:The functional neurogenomics of Huntington's disease
DTSTART:20100924T120000
DTSTAMP:20260502T075330Z
UID:92e8e78ac7a7b7b3d94b30d67aec333febe1ac50fe488ff20bc6fb6c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Ruth Luthi-Carter\nAbstract:  Recent work by the Laboratory of
  Functional Neurogenomics has elucidated new facets of neuronal function a
 nd neurodegeneration at the molecular and cellular levels. Our research fo
 cuses primarily on the dominantly inherited neurodegenerative disorder kno
 wn as Huntington’s disease (HD)\, which affects neurons in the basal gan
 glia and cerebral cortex leading to difficulties in motor and psychiatric 
 function. Our system-based approach makes use of quantitative genome-wide 
 RNA analyses to detect mutant huntingtin-induced changes in gene expressio
 n a comprehensive manner. We have succeeded in employing gene expression d
 ata to establish a more complete picture of the disease process as well as
  to formulate novel hypotheses about how HD-affected neurons die or can be
  rescued from neurotoxicity. Our work has established benchmark data and a
 nalyses\, identified new disease-related mechanisms\, and tested novel HD 
 therapeutic strategies. In parallel\, we have developed new tools and para
 digms for combining molecular and cellular information to benefit CNS drug
  discovery. In this seminar\, I will describe how our gene expression stud
 ies of HD-related systems have yielded new insights into the etiology and 
 treatment of neurodegenerative states and also contributed to understandin
 g the basic mechanisms via which striatal and cortical neurons develop and
  function.
LOCATION:SV 1717 A
STATUS:CONFIRMED
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