BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Development of Metal-Mediated Direct C-H Amination Reactions
DTSTART:20140919T171500
DTEND:20140919T181500
DTSTAMP:20260928T194056Z
UID:9eaf196e5c65017e93796be1c837ab706c4ebd5274ac35b6c2736a23
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sukbok Chang\, Center for Catalytic Hydrocarbon Function
 alizations\, Institute of Vasic Science (IBS) and KAIST\, Korea\nAryl amin
 es are a key synthetic unit widely utilized in organic synthesis\, coordin
 ation chemistry\, materials science and pharmaceutical industry. Current r
 outes to those compounds require either prefunctionalized starting materia
 ls or external oxidants\, thus inevitably generating stoichiometric amount
 s of side wastes. We have developed direct amidation and amination reactio
 ns of arene carbon-hydrogen (C-H) bonds using organic azides as the amino 
 source releasing molecular nitrogen as the single by-product. The reaction
  is catalyzed by a cationic rhodium or iridium complex under external oxid
 ant-free conditions\, and a broad range of chelate group-containing arenes
  are selectively amidated and aminated with excellent functional group tol
 erance\, thereby opening a new avenue to environmentally benign carbon-nit
 rogen (C-N) bond formation which can be immediately applied in synthetic c
 hemistry\, medicinal\, and materials science.\nReferences\n1) S. H. Cho\, 
 J. Kim\, J. Kwak\, Sukbok Chang\, Chem. Soc. Rev. 2011\, 40\, 5068-5083.\n
 2) J. Y. Kim\, S. H. Park\, J. Ryu\, S. H. Cho\, S. H. Kim\, S. Chang\, J.
  Am. Chem. Soc. 2012\, 134\, 9110-9113.\n3) J. Ryu\, J. Kwak\, K. Shin\, D
 . Lee\, S. Chang\, J. Am. Chem. Soc. 2013\, 135\, 12861-12868.\n4) K. Shin
 \, Y. Baek\, S. Chang\, Angew. Chem.\, Int. Ed. 2013\, 52\, 8031-8036.\n5)
  S. H. Park\, Y. Park\, S. Chang\, Organic Syntheses 2014\, 91\, 52-59.\n6
 ) S. H. Park\, J. Kwak\, K. Shin\, J. Ryu\, Y. Park\, S. Chang\, J. Am. Ch
 em. Soc.\, 2014\, 136\, 2492-2502.\n7) T. Kang\, Y. Kim\, D. Lee\, Z. Wang
 \, S. Chang\, J. Am. Chem. Soc. 2014\, 136\, 4141-4144.\n8) H. Kim\, K. Sh
 in\, S. Chang\, J. Am. Chem. Soc. 2014\, 136\, 5904-5907.\n9) H. Hwang\, J
 . Kim\, J. Jeong\, S. Chang\, J. Am. Chem. Soc.\, 2014\, 136\, 10770-10776
 .
LOCATION:BCH 2218 https://plan.epfl.ch/?room==BCH%202218
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR