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PRODID:-//Memento EPFL//
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SUMMARY:Mining microbial dark matter for drug development
DTSTART:20141104T161500
DTEND:20141104T171500
DTSTAMP:20260406T212926Z
UID:e39b1ce6a1c2ea31810e5a9626e0d930afe391472c9faaa466fce917
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jörn Piel\, ETH Zürich\, Switzerland\nCulturable bacte
 ria provide many bioactive natural products that serve as an important bas
 is for drug development. By extrapolation it has been proposed that the gr
 eat diversity of as-yet unculturable prokaryotes represents a massive disc
 overy resource for novel drug candidates. However\, little functional insi
 ghts existed about the metabolic potential of these organisms. This talk s
 ummarizes recent findings derived from metagenomic\, single-cell\, and bio
 chemical studies that reveal members of the microbiota in marine sponges a
 nd other macroorganisms as extraordinarily rich producers of structurally 
 distinct\, potent bioactives. The results open attractive avenues for drug
  discovery and targeted studies on the ecological role of microbiomes.
LOCATION:SV1717A
STATUS:CONFIRMED
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