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VERSION:2.0
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SUMMARY:Intracellular activities of Salmonella
DTSTART:20100916T140000
DTSTAMP:20260428T082521Z
UID:72e1e11871ebafd0bb69b18c5f0d0ae62eac55acafb2b25d58d760bf
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David Holden\, Imperial College\, London\nFollowing entr
 y of Salmonella into host cells\, this pathogen remains in a membrane-boun
 d compartment called the Salmonella-containing vacuole (SCV). Bacteria sen
 se both the vacuolar and cyctosolic environments and activate the expressi
 on of the SPI-2 type III secretion system (T3SS)\, and translocation of it
 s effectors. The SPI-2 T3SS has been implicated in several physiological a
 ctivities\, including avoidance of killing by macrophages\, bacterial repl
 ication in a variety of host cell types\, interference with immune signall
 ing and the induction of cytotoxicity. I will describe recent progress in 
 our laboratory on the functions of this complicated system.
LOCATION:SV 1717A
STATUS:CONFIRMED
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