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SUMMARY:Host genetic susceptibility to influenza A infections
DTSTART:20101117T140000
DTSTAMP:20260427T230605Z
UID:d32bd122a16344f7c637f69951f941aa1a35b9c41d698faabfeb89f5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Klaus SCHUGHART \, Dept. Infection Genetics\, Helmholtz Centre
   Infection Res.\, Hannover\, Germany\nTo identify genetic determinants of
  host susceptibility and resistance\, we studied the host response after i
 nfection with influenza A virus in various mouse genetic reference populat
 ions. We used several inbred mouse strains\, recombinant inbred strains (B
 XD) and Interspecific Recombinant Congenic strains (BcG) as well as knock-
 out mutants. Mice were infected with influenza A H1N1 and H7N7 virus. Our 
 studies demonstrated a large effect of the host genetic background on path
 ogenicity\, viral reproduction and survival. Genetic mapping analyses are 
 ongoing to determine the underlying genomic regions in the host. Furthermo
 re\, gene expression analysis and cytokine/chemokine profiles showed stron
 g induction of inflammation-related genes in susceptible DBA/2J mice which
  contribute to a lethal outcome. We also performed a comprehensive analysi
 s of the host-response to influenza virus infection by establishing a time
  series for the host transcriptome in C57BL/6J mice from days 1 to 14 post
  infection. Both cell-specific expression patterns as well as activation o
 f specific pathways were discernible.
LOCATION:SV 1717A
STATUS:CONFIRMED
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