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SUMMARY:A Tale of Two Cytokines - Embryonic Stem Cell Self Renewal and its
  Relationship to Lineage Specification
DTSTART:20140915T121500
DTSTAMP:20260427T215942Z
UID:a1e0c761b1da175d94c3c1056637bb62dcec079ecf3d8fbe9958bc7a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Joshua M. Brickman\, The Danish Stem Cell Centre (DanSte
 m)\, University of Copenhagen (DK)\nDISTINGUISHED LECTURE IN BIOLOGICAL EN
 GINEERINGAbstract:\nRecent observations have suggested that Embryonic Stem
  Cells (ESC) are not a single cell type\, but a complex and heterogeneous 
 culture system.  Our work suggests that underlying this heterogeneity may
  be in vitro selection pressure\, driving individual ESCs\, initially deri
 ved from the early mammalian embryo\, to attempt to rebuild their own nich
 e.  In this context I will also talk about two signaling pathways canonic
 ally associated with ESC self-renewal and pluripotency\, Fgf and Lif\, and
  discuss how they regulate heterogeneity and potency.Bio:\nPh.D. (Biochemi
 stry and Molecular Biology)\, Harvard University (1996)\nB.A. (Chemistry &
  Philosophy)\, University of Vermont (1985)\nJosh Brickman has a backgroun
 d in molecular biology and gene regulation. From a PhD in transcription he
  trained in developmental biology as a post-doctoral fellow\, working in e
 arly mouse\, and Xenopus\, as well as cultivating embryonic stem cells as 
 a model for developmental biology. He began his own lab with research proj
 ects bridging early development in multiple models systems with ES cells i
 n a hybrid approach aimed at understanding conserved mechanisms of pluripo
 tency and self renewal.\nHe currently seeks to understand how transcriptio
 n factors regulate cell fate choice in ES cells and early embryos. More sp
 ecifically\, Professor Brickman’s and his group investigate the basis fo
 r transcriptional priming and commitment in ES cells and early in the spec
 ification of the endoderm lineage. They hope to understand the relevance o
 f these priming events to stem and progenitor cell potency.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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