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SUMMARY:Photoactive Yellow Protein – Converting Light into a Metastable 
 Structural Change
DTSTART:20141023T163000
DTEND:20141023T173000
DTSTAMP:20260509T142145Z
UID:28811f1b6c43420e2132ce66c8fddba3d4949494fe2a3903846ec634
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Marloes Groot\nVU University\, Amsterdam\nTwo questions 
 at the forefront of biophysical sciences are biological sensing and energy
  conversion.  Photoactive Yellow Protein is at the cross point of these t
 wo topics as it converts light energy into a structural change\, in the pr
 ocess of biological light sensing. This bacterial photosensor is an excell
 ent model system to study how a protein achieves such a function as it is 
 relatively small and very stable.\nBiological signal transduction by photo
 active yellow protein (PYP) in halophilic purple sulfur bacteria is initia
 ted by trans-to-cis isomerization of the p-coumaric acid chromophore (pCa)
  of PYP. pCa is engaged in two short hydrogen bonds with protein residues 
 E46 and Y42\, a normal hydrogen bond with Cys69 and it is negatively charg
 ed at the phenolate oxygen. We have applied ultrafast pump-probe spectrosc
 opy in the visible and midinfrared spectral regions to study the rate and 
 quantum yield of the isomerization process\, and the role of the three hyd
 rogen bonds and the role of local charges in the formation of the stable l
 ong-lived isomer.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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