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SUMMARY:Quantum Nanobiology and Applications in Healthcare  with BIGHEART 
  (Bionanoscience for Innovative Global Healthcare Research & Technology)
DTSTART:20140929T110000
DTSTAMP:20260427T220718Z
UID:f9ab1d7c049c8d0185ae186d19c9d46ae90c7fc16b6144bada23306f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Luke P. Lee\, University of California\, Berkeley\, CA (
 USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERINGAbstract:\nIt is crit
 ical time to solve the problems of both developed and developing countries
  healthcare challenges. In the first part of talk\, I will present quantum
  nanobiology (i.e. photonic gene regulation) for the fundamental understan
 ding of gene regulation in human cell biology and translational medicine. 
 High-precision and selective remote controls of nanoscale biophotonic opti
 cal antennas allow real-time\, noninvasive study of gene regulations in li
 ving cells.  Since the abnormal NFKB signaling pathway has been associate
 d in cancer\, infectious diseases\, inflammation\, neurological diseases\,
  and aging\, we found a way to induce the spatiotemporal control of NF-KB 
 regulatory circuitry by selective liberations of IKB siRNA and p65 siRNA f
 rom biophotonic optical antennas. By creating biophotonic gene circuits\, 
 the efficacy of multi-step bidirectional control of specific gene expressi
 on is demonstrated through the expression measurements of IP-10 and RANTES
  activated by nuclear p65.  In addition\, since alternative messenger RNA
  splicing is a fundamental process of gene regulation\, and errors in RNA 
 splicing are known to be associated with a variety of different diseases\,
  we also demonstrated a quantitative method for monitoring mRNA splice var
 iants in living cells using biophotonic optical antennas.\nIn the second p
 art of talk\, I will discuss the applications of quantum nanobiology (i.e.
  photonic gene amplifications) in integrated molecular diagnostic systems 
 (iMDx) and integrative microphysiological analysis platforms (iMAPs) for h
 uman organ functions on chips. The iMDx comprises a self-contained sample 
 preparation from whole blood\, multiplexed protein assays\, and ultrafast 
 nucleic acid amplification assays on chip with a sample-to-answer readout 
 platform. As we gain more insight into the genomic basis of pathogen infec
 tivity and drug resistance\, point-of-care nucleic acid testing with photo
 nic gene amplifications will likely become an important tool for global he
 althcare in both developed and developing countries. I will also discuss t
 he progress on patient-specific iPSCs-based organs on chip\, the iMAPs wit
 h photonic gene circuits for personalized medicine.  This emerging organ 
 on chip technology called iMAPs with multiplexed analysis capability has t
 he potential to become an alternative to 2D and 3D cell cultures and anima
 l models for experimental medicine\, human disease modeling\, drug develop
 ment\, and toxicology. In summary\, I will share my vision for the integra
 tive Translational Engineering\, Arts\, Medicine\, and Sciences (iTEAMS) t
 o transform life sciences and global healthcare.  Creative iTEAMs with BI
 GHEART will allow us to find solutions together for preventive precision m
 edicine and low-cost healthcare systems.Bio:\nLuke P. Lee is Arnold and Ba
 rbara Silverman Distinguished Professor at UC Berkeley.  He is also Co-Di
 rector of Berkeley Sensor & Actuator Center.  He received both his BA and
  PhD from UC Berkeley. Prof. Lee has authored and co-authored numerous pap
 ers on biophotonics\, nanoscale biophysics\, single cell analysis\, microf
 luidic quantitative cell biology\, and biomedical devices. His current res
 earch interests are quantum nanobiology\, integrative molecular diagnostic
 s of infectious and neurodegenerative diseases\, in vitro organogenesis\, 
 bioinspired neural interfaces\, and solving both developed and developing 
 countries healthcare challenges.  (http://biopoets.berkeley.edu)
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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