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SUMMARY:Structure\, function and dynamics of Type VI secretion system
DTSTART:20141007T121500
DTSTAMP:20260408T060407Z
UID:580cc90487babeccd00abc137d89f437475b296c56fd340f6a8b9287
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Marek Basler\, University of Basel\nStructure\, function
  and dynamics of Type VI secretion system\nThe bacterial Type VI secretion
  system (T6SS) is a large dynamic organelle that is functionally analogous
  to contractile tails of bacteriophages. T6SS is used by Gram-negative bac
 teria to inhibit adjacent cells via translocation of toxic effector protei
 ns and thus play an important role in bacterial ecology. We used time-laps
 e fluorescence light microscopy to describe dynamics of Vibrio cholerae T6
 SS. We showed that T6SS sheath\, which powers the secretion\, cycles betwe
 en assembly\, quick contraction\, and disassembly. Single cell analysis of
  subcellular localization of T6SS assembly in Pseudomonas aeruginosa revea
 led that its T6SS organelle is assembled and aimed to specifically retalia
 te against attacks by other bacteria. I will present latest update on the 
 structure\, function and dynamics of T6SS as well on mechanisms of effecto
 r delivery.Marek Basler\nBio: Positions:\nSince 2013 Assistant Professor\,
  Biozentrum\, University of Basel\n2007 – 2013 Postdoctoral Fellow\, Dep
 artment of Microbiology and Immunology\, Harvard Medical School\, Boston\,
  USA.\nSupervisor: John Mekalanos\, Ph.D.\nEducation:\n2002 – 2007 Ph.D.
  studies\, Institute of Microbiology\, CAS\, Prague\, Czech Republic. Supe
 rvisor: Peter Sebo\, Ph.D.\n1999 – 2002 Undergraduate studies. Institute
  of Microbiology\, CAS\, Prague\, Czech Republic.\nSupervisor: Peter Sebo\
 , Ph.D.\nSelected Awards & Honors:\n2009 EMBO long-term fellowship\n2006 "
 Best Young Microbiologist" Award from the Czechoslovak Society for Microbi
 ology
LOCATION:SV 1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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