BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Linking Regulatory Networks to Transcriptional Identity at the Sin
 gle-Cell Level
DTSTART:20141008T101500
DTSTAMP:20260506T044858Z
UID:db0207299e9e6523ccdabb369de8f4d18687ffbb86ff6a1434d59f51
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Martin Jakt\, Keio University School of Medicine\, Tokyo
  (Jpn)\nBIOENGINEERING SEMINARAbstract:\nDuring developmental differentiat
 ion cells confront numerous cell fate decisions. These decisions are deter
 mined\, or at least influenced by the integration of external signals with
  internal state through gene regulatory networks. The output of this proce
 ss is an increasingly complex set of transcriptional identities that can b
 e considered as a phase space occupancy. Research on bulk populations of c
 ells has been very successful at identifying important components of the r
 egulatory processes\; however\, relatively little is known about the quant
 itative relationships between components and this means that the resulting
  networks have little or no predictive power. Such information has been di
 fficult to obtain as measurements need to be performed at the single cell 
 level. We have been tackling this problem by developing in situ based meth
 ods for quantifying transcriptional identity within single cells through t
 he direct counting of gene transcripts. This has allowed us to consider ho
 w transcriptional identity changes during differentiation of lateral mesod
 erm and we have combined this with inducible transcription factor expressi
 on to start to quantify the underlying regulation. In future work I wish t
 o combine quantification of the transmission of external signals with the 
 transcriptional response in order to dissect the mechanisms that drive cel
 l fate decisions.Bio:\n1993 　BSc(hons) in Biochemistry 2.1\, University 
 of London\, UK\n1998 　Completion of PhD at the department of Biochemistr
 y\, University of Hong Kong\n1999 – 2001   Postdoctoral Research\, Dep
 artment of Biochemistry\, University of Hong Kong\n2001 – 2005   Visit
 ing Scientist\, Department of Molecular Genetics\, Kyoto University (- Apr
 il 2002) and research scientist at Riken Center for Developmental Biology\
 , Kobe\, Japan\n2005 – 2013   Research Scientist Riken Center for Deve
 lopmental Biology\, Kobe\, Japan\n2013 – present   Project Senior Assi
 stant Professor\, Department of Systems Medicine\, Mitsunada Sakaguchi Lab
 oratory\, Keio University School of Medicine\, Tokyo\, Japan
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR