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SUMMARY:Direct Visualization of Dynamic Biomolecular and Cellular Processe
 s by High-Speed Atomic Force Microscopy
DTSTART:20141020T121500
DTSTAMP:20260929T064114Z
UID:b483e343e307715c817c9da4cc11d58577b9df35c644a230545df80e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Toshio Ando\, Kanazawa University (Japan)\nDISTINGUISHED
  LECTURE IN BIOLOGICAL ENGINEERINGAbstract:\nProteins are dynamic in natur
 e and function at the single molecule level. Therefore\, directly observin
 g individual molecules at high spatiotemporal resolution must be a straigh
 tforward approach to understanding how proteins function. Although atomic 
 force microscopy (AFM) allows us to observe individual molecules in physio
 logical solutions\, its low imaging rate has limited its usefulness in lif
 e sciences. To overcome this problem\, various efforts have been carried o
 ut in the last two decades and consequently high-speed AFM has now come of
  age. It can film protein molecules in action at sub-100 ms temporal and s
 ub-molecular spatial resolution without disturbing their function. Various
  application studies carried out so far on protein specimens have provided
  not only corroborative “visual evidence” for previous inferences of t
 heir molecular processes but also resolved long-standing questions that ha
 ve previously been difficult or impossible to address by traditional appro
 aches. Therefore\, the filmed images have successfully provided more and d
 eeper insights into how the proteins operate to function. High-speed AFM t
 echniques have now being further advanced in various directions: wide-area
 /fast scanning\, sample manipulation during imaging\, tip-scan mode for la
 rge samples\, and combination with light microscopy techniques. Some of th
 ese developments have already made it possible to visualize dynamic events
  occurring in live cells. Thus\, high-speed AFM will become a more useful 
 tool for biological research and assist new discoveries.Bio:\nToshio Ando 
 studied physics\, applied physics\, and biophysics at Waseda University an
 d received his Dc. Sci. degree in 1980 from Waseda University. After worki
 ng on the mechanism of muscle contraction and fluorescence techniques for 
 six and half years as a postdoctoral fellow and then an assistant research
  biophysicist at UC San Francisco (Manuel Morales’s lab)\, he was appoin
 ted to the faculty at Kanazawa University\, where he is currently a Full P
 rofessor of Physics and the Director of the Bio-AFM Frontier Research Cent
 er. His research interests include the elucidation of functional mechanism
  of proteins\, particularly of motor proteins\, and the instrument develop
 ment of high-speed scanning probe microscopes. He has received many awards
  for his development of high-speed AFM and its biological applications.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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