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SUMMARY:"Exploring Cortex in a High-Throughput Manner by Building Brain Ob
 servatories”
DTSTART:20141103T163000
DTEND:20141103T173000
DTSTAMP:20260509T150312Z
UID:28eae277969996712d7e51bf6c00117d7e52c4f82a36f37598804e76
CATEGORIES:Conferences - Seminars
DESCRIPTION:Christof Koch\, Ph.D.\nChief Scientific Officer\nAllen Institu
 te for Brain Science\, Seattle\, USA\nThe Allen Institute for Brain Scienc
 e has\, over the past ten years\, produced a series of brain atlases (www.
 brain-map.org). These are large (3 TB\, >1 million slides) public resource
 s\, integrating genome-wide gene expression\, and neuroanatomical data acr
 oss the entire brain for developing and adult humans\, non-human primates 
 and mice\, complemented by high-resolution\, cellular-based anatomical con
 nectivity data in several thousand mice. It is the largest integrated neur
 oscience database world-wide. Anybody can freely access this data without 
 any restrictions.\nWe are embarked on an ambitious 10-year initiative to u
 nderstand the structure and function of the neocortex and associated satel
 lite structures in humans and mice. We are setting up high through-put pip
 elines to exhaustively characterize the morphology\, electrophysiology and
  transcriptome of cell types as well as their synaptic interconnections in
  the human neocortex (via a combination of fetal\, neurosurgical and post-
 mortem tissues & human stem cells differentiated into forebrain neurons) a
 nd in the laboratory mouse. We are building brain observatories to image t
 he activities of neurons throughout the cortico-thalamic system in behavin
 g mice\, to record their electrical activities\, and to analyze their conn
 ectivity at the ultra-structural level. We are constructing biophysically 
 detailed as well as simplified computer simulations of these networks and 
 of their information processing capabilities. We are now reaching out to t
 he community to understand the type of data and meta-data for such observa
 tories of most use to scientists.
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STATUS:CONFIRMED
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