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SUMMARY:Electronic Label-Free Biosensing Assays
DTSTART:20141103T121500
DTSTAMP:20260406T214513Z
UID:6f5025de5a94df8180b6d357a744edd2f4b98e5aa17040bc4f3c7497
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mark A. Reed\, Yale University\, New Haven\, CT (USA)\nD
 ISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERINGAbstract:\nNanoscale electro
 nic devices have the potential to achieve exquisite sensitivity as sensors
  for the direct detection of molecular interactions\, thereby decreasing d
 iagnostics costs and enabling previously impossible sensing in disparate f
 ield environments.  Semiconducting nanowire-field effect transistors (NW-
 FETs) hold particular promise\, though contemporary NW approaches are inad
 equate for realistic applications and integrated assays.  We present here
  an integrated nanodevice biosensor approach [1] that is compatible with C
 MOS technology\, has achieved unprecedented sensitivity\, and simultaneous
 ly facilitates system-scale integration of nanosensors.  These approaches
  enable a wide range of label-free biochemical and macromolecule sensing a
 pplications\, such as specific protein and complementary DNA recognition a
 ssays\, and specific macromolecule interactions at femtomolar concentratio
 ns. \nCritical limitations of nanowire sensors are the Debye screening li
 mitation [3]\, and the lack of internal calibration for analyte quantifica
 tion\, which has prevented their use in clinical applications and physiolo
 gically relevant solutions.  We will present approaches that solve these 
 longstanding problems\, which demonstrate the detection at clinically impo
 rtant concentrations of biomarkers from whole blood samples [4]\, integrat
 ed assays of cancer biomarkers [5]\, and the use of these as a quantitativ
 e tool for drug design and discovery\, including binding kinetics [6] and 
 chirality detection [7].\n[1] Nature\, 445\, 519 (2007)\n[2] Elect. Dev. L
 ett. 31\, 615 (2010)\n[3] Nano Lett. 7\, 3405 (2007)\n[4] Nature Nanotech.
  5\, 138 (2010)\n[5] Biosens. Bioelectron.\, 28\, 239 (2011).\n[6] Nature 
 Nano. 7\, 401 (2012).\n[7] ACS Nano 7\, 4014 (2013).Bio:\nProf. Mark A. Re
 ed received his Ph.D. in Physics from Syracuse University in 1983\, after 
 which he joined Texas Instruments.  In 1990 Mark joined Yale University w
 here he holds the Harold Hodgkinson Chair of Engineering and Applied Scien
 ce\, and is the Associate Director of the Yale Institute for Nanoscience a
 nd Quantum Engineering.  His research activities have included the invest
 igation of electronic transport in nanoscale and mesoscopic systems\, arti
 ficially structured materials and devices\, molecular scale electronic tra
 nsport\, plasmonic transport in nanostructures\, and chem/bio nanosensors.
   Mark is the author of more than 180 professional publications and 6 boo
 ks\, has given 19 plenary and over 260 invited talks\, and holds 25 U.S. a
 nd foreign patents on quantum effect\, heterojunction\, and molecular devi
 ces.  He has been elected to the Connecticut Academy of Science and Engin
 eering and Who's Who in the World.  His awards include\; Fortune Magazine
  “Most Promising Young Scientist” (1990)\, the Kilby Young Innovator A
 ward (1994)\, the Fujitsu ISCS Quantum Device Award (2001)\, the Yale Scie
 nce and Engineering Association Award for Advancement of Basic and Applied
  Science (2002)\, Fellow of the American Physical Society (2003)\,  the I
 EEE Pioneer Award in Nanotechnology (2007)\, and Fellow of the Institute o
 f Electrical and Electronics Engineers (2009).
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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