BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Memento EPFL// BEGIN:VEVENT SUMMARY:Optofluidic Bio-Lasers: Bridging Photonics\, Nanotechnology and Bi ology DTSTART:20141105T090000 DTSTAMP:20260929T050149Z UID:3db4b8f6ac2bbf0f77a40133263b73068ba67f7b0cd365132d5d1f15 CATEGORIES:Conferences - Seminars DESCRIPTION:Prof. Xudong Fan\, University of Michigan\nAbstract:\nThe opto fluidic laser is an emerging technology that integrates microfluidics\, mi niaturized laser cavity\, and laser gain medium in liquid\, thus well posi tioned to interface photonics\, biology\, and nanotechnology. Presently\, the optofluidic laser is being investigated for two forefront applications : novel photonic devices that can be controlled by micro/nanofluidics and/ or biochemical processes\, and biochemical sensing that takes advantage of its unique biocompatible aqueous environment and signal amplification mec hanism. This presentation focuses on the latter one. In an optofluidic bio -laser\, biochemically related materials (such as dyes and fluorescent pro teins) are used as the gain medium and the biological processes (such as D NA hybridization\, protein conformational change\, etc.) take place inside a laser cavity. Instead of fluorescence\, laser emission is used as the s ensing signal.\nAccording to the laser theory\, the laser intensity is hig hly dependent upon the laser gain. A small perturbation in the laser gain medium modulated by biological processes will lead to a significantly chan ge in the laser output. Therefore\, by detecting or monitoring the laser o utput change\, the underlying biological process can be sensitively analyz ed.To date\, the optofluidic bio-laser has been employed in DNA and protei n detection\, monitoring of biomolecular conformational changes\, and cell analysis\, showing capabilities unmatched by fluorescence based detection . Various biochemically related materials\, including dyes\, quantum dots\ , luciferins\, Vitamins\, enzyme-activated substrates\, and fluorescent pr oteins\, have been shown to be a suitable candidate for the laser gain med ium. Different laser cavity designs\, such as optical ring resonators\, Fa bry-Pérot cavities\, and distributed feedback gratings\, have also been e xplored to improve the laserperformance.\nDespite the above achievement\, the optofluidic bio-laser is still in its infancy. Tremendous work is need ed to bring this new technology to practical use. It is hopeful that this presentation will stimulate interest in and further investigation of the o ptofluidic bio-laser among the photonic and biochemical sensing communitie s.Bio:\nProf. Fan obtained B.S. and M.S. from Peking University (China) in 1991 and 1994\, respectively\, and Ph.D. in physics andoptics from Oregon Center for Optics at the University of Oregon (USA) in 2000. Between 2000 and 2004\, he was a project leader at 3M Company on fiber optics and phot onic sensing devices for biomedical applications. In August of 2004\, he j oined the Department of Biological Engineering at the University of Missou ri as an Assistant Professor and was early-promoted to Associate Professor in 2009. In January of 2010\, he joined the Biomedical Engineering Depart ment at the University of Michigan. In 2014\, he was early-promoted to Pro fessor and waselected as Fellow of Optical Society of America.\nProf. Fan ’s research includes photonic bio/chemical sensors\, micro/nano-fluidics \, optofluidics\, and nano-photonics for disease diagnostics and bio/chemi cal molecule analysis. In particular\,\n(1) ultrasensitive optical label-f ree biosensors\;\n(2) microfluidic optomechanics\;\n(3) optofluidic lasers \;\n(4) optofluidic ELISA development for sensitive and rapid biomolecular analysis\;\n(5) multi-dimensional micro-gas chromatography instrument dev elopment for portable and wearable vapor detection\; and\n(6) study and de velopment ofnovel optical and non-optical sensors.\nHe has over 100 peer-r eviewed publications and approximately 20 issued/pending patents. Presentl y\, Dr. Fan serves as Associate Editor of Optics Express\, responsible for optical biological and chemical sensors and optofluidics\, and as a chair and organizer of numerous conferences for OSA\, SPIE\, and MRS. He is a r ecipient of 3M Non-Tenured Faculty Award\, American Chemical Society Petro leum Research Fund Award for Young Faculty\, the Wallace H. Coulter Early Career Award (Phase I and Phase II)\, and the National Science Foundation CAREER Award. His research has been supported by the National Science Foun dation\, National Institute of Health\, Environmental Protection Agency\, private foundations\, and industrial companies. LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a STATUS:CONFIRMED END:VEVENT END:VCALENDAR