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SUMMARY:Nanopores and Nanostructures for Biophysics Experiments from Singl
 e Molecules to Bacteria
DTSTART:20141215T141500
DTSTAMP:20260919T215349Z
UID:bdf83cdc32c368fecd938c83c2bc313f68c32d583b02f91977b1b92a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Cornelis "Cees" Dekker\, Delft University of Technology\
 , Delft (NL)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERINGAbatract:\nNa
 notechnology offers many opportunities to contribute to biology. Here I wi
 ll present examples where nanofabrication – the ability to make confined
  structures with dimensions at will – is used to examine the biophysics 
 of single molecules and cells. I will present two major examples from our 
 lab:\n1. DNA translocation through solid-state nanopores [1]\nSolid-state 
 nanopores have proven to be a surprisingly versatile probe for single-mole
 cule analysis of DNA. I will describe some of our recent efforts to expand
  the capabilities of solid-state nanopores even further\, in the direction
  of single-protein detection\, graphene nanopores\, plasmonic nanopores\, 
 and DNA origami nanopores.\n2. Exploring biophysics of bacteria with nanof
 abricated shapes [2]\nWe shape bacteria into forms that deviate from their
  natural phenotype. Specifically\, I will show our ability to shape live E
 . coli bacteria into novel shapes such as rectangles\, squares\, triangles
  and circles. We study pattern formation in these geometries. I will show 
 spatiotemporal oscillations of Min proteins – associated with cell divis
 ion – in such artificial geometries of live E. coli cells.\nReferences:\
 n[1] C. Dekker\, Solid-state nanopores\, Nature Nanotechnol. 2\, 209−215
  (2007)\n[2] F. Wu et al\, submittedBio:Education:\n• 1977-1983 Experime
 ntal Physics at the University of Utrecht\n• 1984-1988 Ph.D. in Physics 
 from University of Utrecht\; thesis "Two-dimensional spin glasses"Academic
  appointments:\n• 1984-1988 Research assistant at the University of Utre
 cht\n• 1988-1993 Assistant professor (UD) at the University of Utrecht\n
 • 1990-1991 Visiting researcher at IBM Research\, Yorktown Heights\, USA
 \n• 1993-1999 Associate professor (UHD) at Delft University of Technolog
 y\n• Since 1999 Antoni van Leeuwenhoek full professor at Delft Universit
 y of Technology.\n• 2000 Visiting researcher at Technion – Israel Inst
 itute of Technology\, Haifa\, Israel\n• Since 2000 Full professor of Mol
 ecular Biophysics\, Delft University of Technology.\n• Since 2001 Group 
 leader of the Molecular Biophysics group\n• Since 2006 Distinguished Uni
 versity Professor\n• Since 2009 Department Chair of the new Department o
 f Bionanoscience\, TU Delft.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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