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SUMMARY:TO BE RESCHEDULED - Imaging Cell Adaptation to Starvation: Roles o
 f Mitochondria\, Lipid Droplets and Autophagy
DTSTART:20150420T121500
DTSTAMP:20260924T200136Z
UID:dbbab8d6b8c74211f6c88ab7c63df7793a50332d0f7fa16bf4c77255
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jennifer Lippincott-Schwartz\, National Institutes of He
 alth\, Bethesda\, MD (USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERIN
 GAbstract:\nWhen cells face conditions of nutrient deprivation\, they call
  upon an evolutionary conserved process involving metabolic reprogramming 
 from glucose metabolism to mitochondria fatty acid oxidation. While the bi
 ochemical basis for this metabolic switch is well established\, how it is 
 regulated cell biologically is unclear. Here\, I describe our results usin
 g live cell imaging to visualise the key organelles and metabolites (i.e.\
 , fatty acids) involved in this metabolic reprogramming and how they opera
 te to ensure cell survival under starvation. We found that cytoplasmic lip
 ases\, autophagy and mitochondria fusion dynamics work cooperatively to en
 sure robust trafficking of fatty acids to mitochondria for energy producti
 on. When any of these components are disrupted\, starved cells do not boos
 t their oxidative metabolism\, and cell survival is diminished. These resu
 lts help clarify how cells cope with nutrient stress\, and are relevant fo
 r understanding metabolic diseases such as diabetes and obesity.Bio:\nDr. 
 Jennifer Lippincott-Schwartz attended Swarthmore College graduating with h
 onors in 1974. After several years of teaching\, she turned to laboratory 
 research working with Dr. Phil Hanwalt at Stanford University receiving a 
 Master's degree in Biology in 1979. Dr. Lippincott-Schwartz then entered t
 he Ph.D. Program in Biology at Johns Hopkins University studying under the
  mentorship of Dr. Douglas Fambrough. After doing post-doctoral work in th
 e laboratory of Richard Klausner at the National Institutes of Health in B
 ethesda\, Maryland\, she established her own lab at the National Institute
 s of Health and is now Chief of the Section on Organelle Biology in the Ce
 ll Biology and Metabolism Branch.\nDr. Lippincott-Schwartz uses live cell 
 imaging approaches to analyze the spatio-temporal behavior and dynamic int
 eractions of molecules in cells. These approaches have helped to change th
 e conventional 'static' view of protein distribution and function in cells
  to a more dynamic view that integrates information on protein localizatio
 n\, concentration\, diffusion and interactions that are indiscernible from
  protein sequences and in vitro biochemical experiments alone.\nDr. Lippin
 cott-Schwartz's projects cover a vast range of cell biological topics\, in
 cluding protein transport and the cytoskeleton\, organelle assembly and di
 sassembly\, and the generation of cell polarity. Analysis of the dynamics 
 of fluorescently labeled proteins expressed in cells is performed using nu
 merous live cell imaging approaches\, including FRAP\, FCS and photoactiva
 tion. Most recently\, her research employs photoactivation localization mi
 croscopy\, called PALM\, that enables visualization of molecule distributi
 ons at high density at the nano-scale. Dr. Lippincott-Schwartz serves as E
 ditor for Current Protocols in Cell Biology and The Journal of Cell Scienc
 e and she is on the Editorial Boards of Cell\, Molecular Biology of the Ce
 ll and Traffic. She is an active member of the scientific community\, serv
 ing as a member of the Council for the American Society of Cell Biology an
 d on the Executive Board of the Biophysical Society. She was elected to th
 e National Academy of Sciences in 2008.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CANCELLED
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