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SUMMARY:Exploring the Design Space of Stripe-Forming Networks
DTSTART:20150518T121500
DTSTAMP:20260506T154503Z
UID:5f13b3c0d186aa24dc585c355cc7691ec09eaad91b3c976756d0ac39
CATEGORIES:Conferences - Seminars
DESCRIPTION:Yolanda Schaerli\, Ph.D.\, University of Zurich (CH)\nBIOENGIN
 EERING SEMINARAbstract:\nGene regulation networks are essential for the pr
 ocessing of information that cells receive. To study the function and prop
 erties of gene regulatory networks synthetic biology is a promising tool. 
 Gene circuits with predefined behaviours have been successfully built and 
 modelled\, but largely on a case-by-case basis. We went beyond individual 
 networks and explored both computationally and synthetically the design sp
 ace of possible dynamical mechanisms for 3-node stripe-forming networks. F
 irst\, we computationally tested every possible 3-node network for stripe 
 formation in a morphogen gradient. We discovered four different dynamical 
 mechanisms to form a stripe and identified the minimal network of each gro
 up. Next\, with the help of newly established engineering criteria we buil
 t these four networks synthetically and showed that they indeed operate wi
 th four fundamentally distinct mechanisms. Finally\, this close match betw
 een theory and experiment allowed us to infer and subsequently build a 2-n
 ode network that represents the archetype of the explored design space.Bio
 :\n2014 - present  SNSF Ambizione fellow\, Institute of Evolutionary Biol
 ogy and Environmental Studies\, University of Zurich\, Switzerland\n2012 -
  2014  Marie Curie post-doctoral fellow\, EMBL/CRG Systems Biology Resear
 ch Unit\, Centre for Genomic Regulation (CRG)\, Barcelona\, Spain\n2011 
 – 2012  SNSF post-doctoral fellow\, EMBL/CRG Systems Biology Research U
 nit\, Centre for Genomic Regulation (CRG)\, Barcelona\, Spain\n2007 - 2010
   PhD researcher\, Departments of Biochemistry and Chemistry\, University
  of Cambridge\, UK\n2002 - 2006  MSc in Biochemistry and Molecular Biolog
 y\, ETH Zurich\, Switzerland
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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