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SUMMARY:Decoding Transcriptional Regulation
DTSTART:20150608T121500
DTSTAMP:20260407T135608Z
UID:4ae62ba72fc02a7390fb88df96d792d2ed39f3c82564612d4370a326
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Alexander Stark\, Research Institute of Molecular Pathol
 ogy - IMP\, Vienna (AT)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERINGAb
 stract:\nIn higher eukaryotes\, genes are expressed dynamically in complex
  spatial and temporal patterns\, which are progressively refined to set up
  body plans and define specific cell-types. I am presenting our work towar
 ds understanding transcriptional regulation in Drosophila by an interdisci
 plinary approach. We functionally characterize regulatory sequences by enh
 ancer screens and by determining tissue-specific regulator binding. Comput
 ational motif analyses coupled to supervised machine-learning methods are 
 powerful tools that allow us to determine motifs that are shared in functi
 onally related sequences and are promising candidates to explain regulator
 y function. We also study how enhancers activate different types of promot
 ers and how enhancer – core-promoter specificity is encoded in the two e
 lements’ sequences. We finally dissect the combinatorics of transcriptio
 n factors and transcriptional cofactors at enhancers by directed tethering
  in enhancer complementation assays\, which revealed functionally distinct
  classes of transcription factors and cofactors.Bio:Education:\n2004  PhD
  in Bioinformatics\, EMBL Heidelberg & University of Cologne\, Germany\n20
 00  M.Sc in Biochemistry (German Diplom)\, University of Tübingen\, Germ
 anyPositions:\n2008 -   Group-leader\, Research Institute of Molecular P
 athology (IMP)\, Vienna\, Austria\n2005 - 2008  Postdoctoral Fellow\, Kel
 lis & Lander Groups\, The Broad Institute of MIT and Harvard and CSAIL MIT
 \, Cambridge\, USA\n2001 - 2005  PhD Student & Postdoc\, Russell Group\, 
 EMBL\, Heidelberg\, Germany\nThesis: "Functional Sites in Structure and Se
 quence - Protein Active Sites and microRNA Target Recognition"\n2000 - 200
 1   Diploma Student & Research Assistant\, Schuster Group\, Friedrich-Mie
 scher-Laboratory\, Tübingen\, Germany\nThesis: "The Novel GTP-binding Pro
 tein dNOG is involved in the Synaptic Plasticity of Drosophila Neuromuscul
 ar Junctions"
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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