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SUMMARY:Developmental Syndromes Underlying the Evolution of Reproductive I
 solation in Mammals
DTSTART:20141112T101500
DTSTAMP:20260406T161420Z
UID:fad93eb30ebe391638e3300b0d698a3001cb8f220909ab3ab2e7be69
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jeffrey M. Good\, University of Montana\, Missoula\, MT 
 (USA)\nBIOENGINEERING SEMINARAbstract:\nHybrid defects manifest from devel
 opmental pathways that have diverged rapidly between species\, providing p
 owerful insights into the genetic underpinnings of diversification and ada
 ptation. Yet we still do not have a clear sense of if certain developmenta
 l processes are especially prone to disruption in hybrids. I will discuss 
 our recent speciation genetics research focused on two developmental proce
 sses – spermatogenesis and embryonic development – that appear to be c
 ommonly disrupted in mammalian hybrids. We have used genetic crosses and g
 enome-wide surveys of gene expression to localize incompatibilities causin
 g hybrid inviability and male sterility to specific developmental time poi
 nts. Epistatic interactions involving the X chromosome and disturbance of 
 epigenetic regulation of gene expression play central roles in the evoluti
 on of both phenotypes. These intriguing results suggest that disparate for
 ms of intrinsic reproductive isolation in mammals may reflect the recurren
 t disruption of key developmental processes through similar genetic mechan
 isms.Bio:\nAssistant Professor\, University of Montana (2010-present)\nNSF
  Postdoctoral Fellow\, Max Planck Inst\, Leipzig\, Germany\, 2008-2010\, (
 Pääbo Lab)\nPhD\, Ecology & Evolutionary Biology\, 2007 (Nachman Lab)\nM
 S\, Biology\, University of Idaho\, 2002 (Sullivan Lab)\nBS\, Zoology\, Un
 iversity of Idaho\, 1999
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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