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SUMMARY:Rational protein purification from transgenic feedstock – tobacc
 o leaf extract as a challenging example
DTSTART:20141202T091500
DTEND:20141202T101500
DTSTAMP:20260408T085036Z
UID:f16b9fb2c6553b5e87618bfafa4bee9e1242e144cb00fa76d2c5b5a2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Johannes F. Buyel\, M. Sc.\, Institute for Molecular Biote
 chnology\, RWTH Aachen University\nMany feed streams in the biopharmaceuti
 cal production of proteins\, e.g. monoclonal antibodies\, have to be clari
 fied before the dissolved target can be isolated\, e.g. by chromatography.
  Disposable filters\, flocculants and precipitation methods offer a cost-e
 ffective\, fast and safe way to achieve this goal. After clarification\, c
 hromatographic unit operations are most frequently used to purify the targ
 et protein until the required purity is reached\, typically >99% for pharm
 aceutical applications. The seminar will highlight some recent achievement
 s in clarifying biological feedstocks derived from plants and then focus o
 n the rational design and optimization of downstream purification strategi
 es for recombinant target proteins. Topics such as modeling chromatographi
 c separations and planning experimental verification will be covered.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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