BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Metabolic signaling: role of nuclear and membrane receptors
DTSTART:20141128T123000
DTEND:20141128T133000
DTSTAMP:20260916T043954Z
UID:cacc4ec47f42042c8f8ac36c5fece1b55af608a399b3462616c8e242
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Kristina Schoonjans\, GR-SCH\, IBI\, SV\, EPFL\nAbstract:\n
 My interest is to understand the molecular basis by which metabolites in g
 eneral\, and bile acids in particular\, signal to convey adaptive response
 s in metabolic organs. I will illustrate this principle by two vignettes. 
 The first focuses on the nuclear receptor\, liver receptor homolog 1\, for
  which we identified roles in multiple processes\, ranging from the contro
 l of bile acid composition to the regulation of liver intermediary metabol
 ism.\nIn this talk I will describe the molecular mechanism how a selective
  gain-of-function mutation of LRH-1 that disrupt its SUMOylation on a sing
 le residue\, enhances bile acid secretion and reverse cholesterol transpor
 t\, which on a systemic level translates in a remarkable protection agains
 t atherosclerosis. My second example will focus on the bile acid-activated
  GPCR\, TGR5\, which we established as vital for energy expenditure\, gluc
 ose homeostasis and macrophage inflammation in the vessel wall. I will sho
 w how TGR5 activation reduces chemokine expression in macrophages via mTOR
 -dependent enhanced translation of the dominant-negative C/EBP-LIP isoform
  and decreases the recruitment of macrophages to the adipose tissue\, ther
 eby contributing to the insulin sensitization induced by bile acids.\nThro
 ugh focusing on metabolite sensing pathways my laboratory has hence identi
 fied novel mechanisms that contribute to the pathogenesis of common metabo
 lic disorders\, such as type 2 diabetes and atherosclerosis. We hope that 
 these insights one day can be applied to develop new preventive and therap
 eutic strategies for these pervasive diseases.Bio:\nKristina Schoonjans is
  Lecturer in Biochemistry and Research Professor at the Ecole Polytechniqu
 e Fédérale in Lausanne (EPFL)\, Switzerland\, where she studies the role
  of nuclear and membrane receptors in metabolism and bile acid signalling.
  She obtained her Ph.D in Molecular Biology and Pharmacology from the Univ
 ersity of Lille\, France in 1995 for her work on the role of the PPAR nucl
 ear receptor family in metabolism. She continued her academic career in th
 e same research area during her postdoctoral training at the Institut Past
 eur de Lille until 1999. She then moved to the Institut de Génétique de 
 Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg first as a resea
 rch scientist and later in 2007 as a research director with INSERM. Kristi
 na Schoonjans is member of the editorial board of Molecular Endocrinology 
 and Molecular and Cellular Endocrinology.
LOCATION:SV1717a http://plan.epfl.ch/?lang=en&room=sv+1717a
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR