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SUMMARY:LCN Seminar: Dynamics of the neuromodulator adenosine
DTSTART:20141127T133000
DTSTAMP:20260916T044008Z
UID:b468083fc89df01bb9f8fee2bd141c207395ce326651bcf7156413f7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Magnus RICHARDSON\; Systems Biology Centre\, University of War
 wick\nFast activity in neuronal networks can be strongly affected by a var
 iety of neuromodulators. One such neuromodulator\, adenosine\, has a suppr
 essive effect on activity and its transport in tissue and action on the pr
 incipal cells of the neocortex will be the focus of this talk. The complex
  dynamics of diffusive signalling molecules in tissue is poorly understood
  and has been relatively neglected by the main thrust of computational neu
 roscience\, partly because the extracellular concentration of neuromodulat
 ors has been hard to quantify experimentally. Here we show that simple mat
 hematical models can accurately capture the activity-dependent adenosine-r
 elease waveforms measured by purine biosensors. We also demonstrate that l
 ocalised adenosine concentrations mediate the developmental change from de
 pression to facilitation in the synaptic transmission between neocortical 
 layer-5 pyramidal cells and thereby suggest a novel mechanism for long-ter
 m plasticity in the adult neocortex.
LOCATION:AAC132 http://plan.epfl.ch/?room=AAC132
STATUS:CANCELLED
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