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SUMMARY:Study of resilience\, a second dimension of host defense\, in inte
 stinal infections of the genetic model organism Drosophila melanogaster
DTSTART:20150119T101500
DTEND:20150119T111500
DTSTAMP:20260501T195556Z
UID:4f603b11f287b18b56c767cd927a9f72bf373d62aecdc4cdfef5cb91
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dominique Ferrandon\nHost defense is not limited to immunity a
 nd encompasses the ability to endure and repair damages and to handle toxi
 ns and toxicants. After a general introduction on the Drosophila model and
  the notion of resilience to infections\, I will describe the existence in
  the fly intestine of a common response to Serratia marcescens hemolysin\,
  a pore-forming toxin\, and to xenobiotics such as caffeine\, soft or heav
 y metals\, or a strong oxidant. Exposure of enterocytes to hemolysin leads
  to the rapid formation of megamitochondria and a subsequent controlled ex
 trusion of the cytoplasm along with damaged organelles\, which may constit
 ute a novel repair mechanism. This results in a thin intestinal epithelium
  that recovers its original shape in a few hours. The recovery process req
 uires CyclinJ\, an evolutionary conserved cyclin of hitherto unknown funct
 ion. Finally\, a primary exposure to toxin or xenobiotics induces cross-pr
 otection against a further hemolysin challenge\, thus evoking a hormetic r
 esponse\, which can be elicited by ectopically expressing what else\, a Cy
 clinJ-dependent gene. Thus\, CyclinJ plays a central role in this novel re
 silience mechanism that defends the intestine against infections or intoxi
 cations.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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