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VERSION:2.0
PRODID:-//Memento EPFL//
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SUMMARY:Nuclear receptor regulation of nutrient metabolism 
DTSTART:20101011T121500
DTSTAMP:20260427T203125Z
UID:6140deb907237d1356b515761011978a76ed1d4df1901b29991c6668
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. David J. MANGELSDORF\, Professor & Chair\, University of T
 exas Southwestern Medical Center\, Dallas\,  TX\, USA\nThe ability to regu
 late nutrient metabolism under conditions of excess (i.e.\, after a big me
 al) or deprivation (i.e.\, starvation) is a physiologic process that coinc
 ided with the evolution of nuclear receptors in all multi-cellular organis
 ms. In mammals\, nuclear receptor systems have evolved to respond to chole
 sterol\, bile acids\, and fatty acids and thereby govern nutrient metaboli
 sm in the fed and fasted state. Recently\, we have discovered that this pr
 ocess is conserved in nematodes\, and this has led to the discovery that n
 uclear receptor regulated pathways may be exploited therapeutically to tar
 get two unexpectedly related human diseases: type 2 diabetes and nematode 
 parasitism.
LOCATION:SV 1717A
STATUS:CONFIRMED
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