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SUMMARY:Mass Spectrometry-based Proteomics - Options\, Potential\, limits 
 and future directions
DTSTART:20150218T103000
DTEND:20150218T113000
DTSTAMP:20260407T105848Z
UID:7eadcd7c0006486cace663229affd3bfe1f37cfd2f41d4564dd8e0b7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Yibo WU\, Ph.D.\, Aebersold Lab\, Inst. of Molecular Systems B
 iology\, ETH Zurich (CH)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM a
 nd NUTRITION ALLIANCE (LIMNA)Abstract:\nThe proteome is more than a mere t
 ranslation of a given genome. Proteomics has emerged as a tool to characte
 rize the proteome in various cell types under different conditions. Curren
 tly\, the majority of proteomics strategies rely on mass spectrometric tec
 hniques\, and differ in instrument used and their performance\, reliance o
 n internal standards\, and bioinformatics analysis. These strategies effec
 tively support the identification of proteins and their variants\, i.e. po
 st-translational modifications (PTMs)\, and the quantification of them in 
 various cell types\, organs and species. The pros and cons of each strateg
 y necessitate the consideration of selecting the optimal method based on t
 he specific research interest.\nProteome in different systems have been re
 ported to be nominally correlated with the corresponding genome\, demonstr
 ating the value of integrated multilayered omics approach to test biologic
 al hypothesis or model processes[1\, 2]. Current techniques have generated
  unprecedentedly sensitive\, accurate and reproducible proteomics data\, a
 nd will increase the impact of proteomics in biomedical research.\n1. Gygi
 \, S.P.\, et al.\, Correlation between protein and mRNA abundance in yeast
 . Mol Cell Biol\, 1999. 19(3): p. 1720-30.\n2. Wu\, Y.\, et al.\, Multilay
 ered genetic and omics dissection of mitochondrial activity in a mouse ref
 erence population. Cell\, 2014. 158(6): p. 1415-30.Bio:\nYibo was born in 
 Hunan province\, China. She did her Ph.D. in Research Centre for Proteome 
 Analysis\, Key Laboratory of Systems Biology\, Shanghai Institute for Biol
 ogical Sciences (SIBS)\, Chinese Academy of Sciences (CAS)\, where she dev
 eloped series of strategies for quantitative proteomics and phosphoproteom
 ics research. Yibo joined in Prof. Aebersold group in June\, 2010 and her 
 current research project focus on quantitative proteomics study in hepatic
  insulin resistance using Selected Reaction Monitoring (SRM).
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
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