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SUMMARY:The ins and outs of bacterial bioreporter assays for environmental
  quality measurements
DTSTART:20100927T161500
DTSTAMP:20260916T203806Z
UID:a81ff2db429b6fbc1940875d92ee5eb81479f64d7656757f74123951
CATEGORIES:Conferences - Seminars
DESCRIPTION:van der Meer\, Jan Roelef (UNIL)\nBacterial bioreporter assays
  have been developed as alternative methods for quick\, semi-quantitative 
 measurements of global environmental parameters (e.g.\, 'toxicity') or spe
 cific groups of chemicals (e.g.\, BTEX\, PAHs\, heavy metals). Key element
  in the bioreporter assay is a genetically modified bacterium that can sen
 se the target chemical or conditions\, and\, upon sensing\, produce a read
 out in the form of a so-called reporter protein\, the activity of which is
  easily measurable. Typical reporter proteins include luciferases or fluor
 escent proteins\, that can be measured at high sensitivity. Bioreporter ba
 cteria are thus 'designer' organisms\, in which genetic engineers construc
 t appropriately functioning genetic circuits that produce the necessary el
 ements for the sensing and reporting reaction. This presentation will give
  a brief overview of the elements of bioreporter construction\, such as se
 lecting the appropriate sensor target\, and will then give a number of exa
 mples of versatile use of bioreporter assays as alternatives for chemical 
 analytics (e.g.\, arsenic reporter assays)\, and in bioavailability assays
 .
LOCATION:GR A3 31
STATUS:CONFIRMED
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