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SUMMARY:Toward quantitative description of biological nanomachines: the ex
 ample of contractile injection systems in viruses and bacteria  
DTSTART:20150216T161500
DTEND:20150216T171500
DTSTAMP:20260528T191227Z
UID:684dabf3fcd24dc09a9b30543d52ee620bb881a28defbd3906ed2bb7
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Petr Leiman\nThe process of protein and DNA translocatio
 n across lipid membranes is central to the function of any organism. Bacte
 ria and viruses that infect bacteria have evolved very sophisticated multi
 component systems for transferring various substrates from and into the ba
 cterial cell. These biological nanomachines work with incredible efficienc
 y\, but little is understood about how they achieve this efficiency or how
  they select their substrates. One of the major obstacles to our understan
 ding of these systems is a lack of information about their structure. Over
  the past few years\, we have made a significant progress in describing th
 e structure of some of the most complex of these nanomachines - the bacter
 ial type VI secretion system\, R-type pyocins and contractile tails of com
 plex bacteriophages. These syringe-like nanomachines use a rigid tube-cont
 ractile sheath mechanism for piercing the bacterial membrane. These comple
 xes contain in excess of 1 million of non-hydrogen atoms and are formed by
  hundreds of protein subunits of about 10 different types. My immediate go
 al is to give a quantitative description to how these machines work - how 
 they store energy\, how much of it can be released and what is the kinetic
 s of this process. My long term goal is to use this knowledge to describe 
 other systems participating in protein and DNA translocation across the ba
 cterial cell envelope.
LOCATION:Auditoire CE 1 http://plan.epfl.ch/?lang=fr&zoom=20&recenter_y=58
 64182.50561&recenter_x=731299.44535&layerNodes=fonds\,batiments\,labels\,i
 nformation\,parkings_publics\,arrets_metro\,transports_publics&floor=1&q=c
 e1
STATUS:CONFIRMED
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