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SUMMARY:Intestinal gluconeogenesis: how nutrients and microbiota talk to t
 he brain
DTSTART:20150302T133000
DTEND:20150302T143000
DTSTAMP:20260505T064450Z
UID:9e580fdf8e412951ad21d9e844600fe7ae7f159895f918a2ca6c7abe
CATEGORIES:Conferences - Seminars
DESCRIPTION:Gilles Mithieux - University of Lyon\, France\nThe extrinsic g
 astrointestinal nervous system plays a key role in the sensing of nutrient
 s and hormones and its translation in terms of control of food intake by t
 he central nervous system. Gut gluconeogenesis is a new function with bene
 fits in energy homeostasis. The sensing of gut-released glucose by gastroi
 ntestinal nerves in post-absorptive periods may have a role for example in
  the metabolic benefits of gastric bypass surgeries of obesity (1). Regard
 ing major macronutrients as glucose and protein\, they are sensed by the g
 astrointestinal neural system and the transmission of the signals to the b
 rain promotes satiety phenomena. Glucose is sensed in the portal vein by n
 eurons expressing the glucose receptor SGLT3 and activates the main region
 s of the brain involved in the control of food intake (2\,3). Protein indi
 rectly act on food intake by inducing intestinal gluconeogenesis and the s
 ensing of released glucose by the portal glucose sensor (4\,5). Similarly\
 , soluble fibers and their products (short-chain fatty acids) mediate thei
 r anti-obesity and anti-diabetic benefits via a reflex arc with the brain 
 inducing intestinal gluconeogenesis (6). This new knowledge provides novel
  mechanisms of control of body weight\, which might be useful to envision 
 future approaches of prevention or treatment of obesity and diabetes.
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STATUS:CONFIRMED
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