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SUMMARY:Linking caloric restriction and protection from atherothrombosis -
  mediator role of Sirt1
DTSTART:20150511T133000
DTEND:20150511T143000
DTSTAMP:20260415T132647Z
UID:a7fa8e55220516372d846e8e03d31a2c4cc9d42fd03c11f07321819a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Christian M. Matter\, MD\; Cardiology\, University Heart Cente
 r\, University Hospital Zurich and Center for Molecular Cardiology\, Unive
 rsity of Zurich\nSirtuins (Sirt1-Sirt7) comprise a family of NAD+-dependen
 t enzymes that are activated upon caloric restriction and exercise. They c
 ontrol critical cellular processes in the nucleus\, cytoplasm and mitochon
 dria to maintain metabolic homeostasis\, reduce cellular damage and dampen
  inflammation. These events provide protection against many age-related di
 seases\, including cardiovascular pathologies.\nSirt1 exerts beneficial ef
 fects on cardiovascular risk factors such as diet-induced obesity\, type 2
  diabetes and cholesterol metabolism. Moreover\, Sirt1 provides protection
  from endothelial dysfunction\, atherosclerosis and thrombosis involving m
 olecular targets such as NFB\, LXR\, PCSK9\, LDL-R and eNOS.\nGiven the
  availability of specific Sirt1 activators and the relevance of specific S
 irt1 targets such as PCSK9 in the clinical arena\, it is anticipated that 
 this field will move quickly from bench to bedside.
LOCATION:SV 1717A http://plan.epfl.ch/?lang=fr&zoom=19&recenter_y=5864073.
 98412&recenter_x=730632.15084&layerNodes=fonds\,batiments\,labels\,informa
 tion\,parkings_publics\,arrets_metro\,transports_publics&floor=1&q=SV1717a
STATUS:CONFIRMED
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