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SUMMARY:Convergence of the Wnt\, FGF and TGF-β signaling pathways at the 
 Levels of the Transcription Factors Smad1 and Smad4
DTSTART:20150421T103000
DTEND:20150421T113000
DTSTAMP:20260916T010704Z
UID:1893b788b41c40fb507eeac0c5f9a9b119359ba7da6f1cbab858ca78
CATEGORIES:Conferences - Seminars
DESCRIPTION:Hadrien Demagny\, Ph.D.\, Howard Hughes Medical Institute\, Un
 iversity of California\, Los Angeles\, USA (Pr. De Robertis) and Universit
 é Pierre et Marie Curie\, Paris (F)\nSEMINAR of the LAUSANNE INTEGRATIVE 
 METABOLISM and NUTRITION ALLIANCE (LIMNA)Abstract:\nMy research project ai
 med to understand how cells receive and integrate multiple signals from th
 e extracellular milieu. I focused on Smad proteins and my talk will be div
 ided into two parts. In the first part\, I will describe a new molecular m
 echanism by which the phosphorylation state of the drosophila transcriptio
 n factor Mad determines its ability to transduce either BMP or Wingless (W
 g) signals. In the second part of my talk\, I will describe how Smad4 acti
 vity and stability are directly regulated by the Wnt and FGF signaling pat
 hways through novel MAPK and GSK3 phosphorylation sites located in its lin
 ker region.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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