BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Signal Integration: the Response of Yeast to Mixed Carbon Environm
 ents
DTSTART:20150511T160000
DTSTAMP:20260930T202810Z
UID:37b657af30934575cceabb51339f1c6f26aecea232c2bc127d5439f1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Michael Springer\, Harvard Medical School\, Boston\, MA 
 (USA)\nBIOENGINEERING SEMINARAbstract:\nThe response of yeast to galactose
  is one of the best-studied Eukaryotic signaling pathways. Glucose\, the p
 referred carbon source\, inhibits the utilization of galactose. Surprising
 ly\, we have found that instead of simply inhibiting galactose utilization
  when glucose is above a threshold concentration\, individual cells respon
 d to the ratio of glucose and galactose and based on this ratio determine 
 whether to induce genes involved in galactose metabolism. This response ap
 pears to be the result of an extra layer of signal processing which is occ
 urring at the hexose transporters.\nFurthermore\, we have uncovered natura
 l variation in the threshold of this ratio sensing amongst different natur
 al yeast strain. Competitive growth experiments\, nutrient utilization exp
 eriments\, and gene induction show that cells display two distinct behavio
 rs - a preparation for galactose or an optimization for glucose. These res
 ults suggest that the interaction between multiple nutrient sources maybe 
 more nuanced than previously believed with ratio sensing allowing cells to
  behave more optimally to both steady-state and dynamically changing envir
 onments.Bio:\nThe Springer lab is interested in how evolution shapes and c
 onstrains how organisms respond to their environment. They analyze cellula
 r responses in several related yeast species using a combination of in viv
 o fluorescence\, synthetic and genetic approaches\, and numerical and anal
 ytical modeling.
LOCATION:SV1717a http://map.epfl.ch/?room=sv1717a
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR