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SUMMARY:"Gene Regulation in Space and Time"
DTSTART:20150309T111500
DTEND:20150309T121500
DTSTAMP:20260511T193114Z
UID:248ada71286ea0f074edcb79f70be9b85d06734f7a128d93fb652136
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Caroline UHLER (IST Austria)\nAlthough the genetic infor
 mation in each cell within an organism is identical\, gene expression vari
 es widely between different cell types. The quest to understand this pheno
 menon has led to many interesting mathematics problems. First\, I will pre
 sent a new method for learning gene regulatory networks. It overcomes the 
 limitations of existing algorithms for learning directed graphs and is bas
 ed on algebraic\, geometric and combinatorial arguments.\nSecond\, I will 
 analyze the hypothesis that the differential gene expression is related to
  the spatial organization of chromosomes. I will describe a bi-level optim
 ization formulation to find minimal overlap configurations of ellipsoids a
 nd model chromosome arrangements. Analyzing the resulting ellipsoid config
 urations has important implications for the reprogramming of cells during 
 development. Any knowledge of biology which is needed for the talk will be
  introduced during the lecture.
LOCATION:CIB - BI A0 448 http://plan.epfl.ch/?lang=fr&room=BI+A0+448
STATUS:CONFIRMED
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