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SUMMARY:Lipid membrane bioactivity – novel insights from optical super-r
 esolution (STED-FCS) microscopy
DTSTART:20150507T163000
DTEND:20150507T173000
DTSTAMP:20260501T141528Z
UID:1948227339be7cbf834025fdfba77ea526646b4b627e80e24b9f1e30
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Christian Eggeling\nMRC Human Immunology Unit & Wolfson 
 Imaging Centre Oxford\,\nWeatherall Institute of Molecular Medicine\, Univ
 ersity of Oxford\nMolecular interactions in the plasma membrane of living 
 cells are key in cellular signalling. Especially\, lipids or diffusional r
 estrictions by the cortical cytoskeleton are considered to play a function
 al part in a whole range of membrane-associated processes. The direct and 
 non-invasive observation of such interactions in living cells is often imp
 eded by principle limitations of conventional far-field optical microscope
 s\, specifically with respect to limited spatio-temporal resolution. Here\
 , I show how novel details of molecular membrane dynamics can be obtained 
 by using advanced microscopy approaches such as the combination of super-r
 esolution STED microscopy with fluorescence correlation spectroscopy (STED
 -FCS). These include new insights into the lipid “raft” theory\, and o
 n the role of plasma membrane and cytoskeleton organization in the trigger
 ing of immune cells\, specifically during T-cell activation.
LOCATION:CH G1 495 https://plan.epfl.ch/?room==CH%20G1%20495
STATUS:CONFIRMED
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